Fioricet (butalbital/acetaminophen/caffeine) is a prescription combination medication used to treat tension headaches, typically containing 50 mg butalbital, 325 mg acetaminophen, and 40 mg caffeine. It works by combining a sedative (butalbital) to reduce anxiety, a pain reliever (acetaminophen), and a stimulant (caffeine) to enhance pain relief. Due to the risk of addiction and withdrawal, it is not considered a first-line treatment.
 
Key Information and Warnings
 
Drug Interactions: Do not take with alcohol, sedatives, or monoamine oxidase inhibitors (MAOIs).
Usage: It is meant for short-term, acute treatment of headaches rather than daily management.
Common Side Effects: Sleepiness, dizziness, lightheadedness, and sedation.
Warnings: It is habit-forming due to the butalbital content. Overuse (more than 6-8 capsules a day) can lead to rebound headaches and liver damage from the acetaminophen
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Side Effects and Overdose Symptoms
Serious side effects requiring medical attention include extreme sleepiness, confusion, fainting, shortness of breath, and signs of liver damage (e.g., jaundice, upper stomach pain). Overdose symptoms can include hallucinations, severe dizziness, and shallow breathing.