Percocet (Oxycodone)
Percocet is the brand name for a combination prescription pain medication containing:
- Oxycodone (an opioid pain reliever)
- Acetaminophen (also called paracetamol)
It is used to treat moderate to severe pain when other pain treatments are not sufficient. It is a prescription-only, Schedule II controlled substance in the United States because it has a high potential for misuse, dependence, and addiction.
Available strengths
Common branded formulations include:
| Oxycodone | Acetaminophen | Typical tablet appearance* |
|---|---|---|
| 2.5 mg | 325 mg | Pink, oval |
| 5 mg | 325 mg | Blue, round |
| 7.5 mg | 325 mg | Peach, oval |
| 10 mg | 325 mg | Yellow, capsule/square-shaped |
*Appearance varies for generic manufacturers.
How it works
- Oxycodone binds to opioid receptors in the brain and spinal cord to reduce the perception of pain.
- Acetaminophen helps relieve pain and reduce fever through a different mechanism.
Onset and duration
- Starts working: 20–60 minutes
- Peak effect: 1–2 hours
- Duration of pain relief: 4–6 hours (may vary by person)
Common side effects
- Drowsiness
- Dizziness
- Nausea or vomiting
- Constipation
- Dry mouth
- Itching
- Slowed reaction time
Serious risks
- Slowed or stopped breathing
- Overdose
- Opioid dependence and addiction
- Withdrawal symptoms if stopped abruptly after long-term use
- Liver damage from excessive acetaminophen
- Accidental overdose if combined with other acetaminophen-containing products
Important interactions
Avoid combining Percocet with:
- Alcohol
- Benzodiazepines (such as alprazolam)
- Other opioids
- Sleeping pills or other sedatives
These combinations can greatly increase the risk of life-threatening respiratory depression.

